Light-Activatable Gold Nanoshells for Drug Delivery Applications

Gold Nanoshells for Surface Enhanced Raman Spectroscopy and Drug Delivery

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Gold Nanoshells in Biomedical Applications

Mechano-activatable Microcapsules for Tunable Drug Delivery

Introduction A particularly desirable feature of controlled drug delivery is self-regulation, wherein physiological feedback actively regulates release kinetics. Extant systems in this domain commonly employ stimuli-responsive vehicles that rely on internal triggers to precipitate release, such as temperature, pH, or chemical reactions. 2 The sensitivity of these triggers can be tuned by biomat...

Thermo-Responsive Hydrogel-Coated Gold Nanoshells for In Vivo Drug Delivery

This paper describes the preparation and characterization of a new type of composite nanoparticle, where the structure consists of a nontoxic hydrogel polymer network that encapsulates a gold shell/silica core. These composite nanoparticles are being developed as photothermally responsive drug-delivery vehicles that undergo structural changes slightly above physiological temperature. A unique p...

Hydrogel-Coated Near Infrared Absorbing Nanoshells as Light-Responsive Drug Delivery Vehicles

Nanoparticle drug delivery carriers that can modulate drug release based on an exogenous signal, such as light, are of great interest, especially for improving cancer therapy. A light-activated delivery vehicle was fabricated by synthesizing a thin, thermally responsive poly(N-isopropylacrylamide-co-acrylamide) hydrogel coating directly onto the surfaces of individual near-infrared (NIR) absorb...